Local celebrities Preeta Mehta and her fiancé Ben are greeted, as they arrive, along with their pets Spike and Toots. Who are all, except for Spike, unaware of Jerry stealing from Preeta's handbag. As the couple and their pets are escorted to their room, Jerry's presence is revealed, which puts the wedding and the hotel at risk. Kayla offers to catch Jerry, but fails and realizes that he'll be hard to catch. After many failed attempts, Tom successfully enters the hotel, and his ensuing chase after Jerry wrecks the whole hotel room. Due to noise complaints, Kayla comes to check, but she befriends Tom, due to their shared goal of catching Jerry. Tom is hired by owner Mr. Dubros to exterminate Jerry, while Tom and Kayla's boss Terence threatens to fire them, if Tom fails to catch Jerry.
After many failed attempts, Tom designs an elaborate mouse trap and gets Jerry out of the hotel. Meanwhile, Kayla helps with the wedding plans and learns from Preeta that her engagement ring is missing. Jerry returns and reveals to Kayla that he had Preeta's ring, and he agrees to give it back to her, if she lets him stay in the hotel. Before Kayla can agree, Terence returns from walking Spike, and notices Tom looking for Jerry hiding in Kayla's coat pocket, but creates a huge scene that causes Spike, Tom, and Jerry's ensuing chase to destroy the hotel's lobby.
Terence is put on leave, while Kayla is promoted as event manager, for returning the ring stolen by Jerry. Kayla tells Tom and Jerry that they will have to get along and spend the next day far away from the hotel together, if they want to stay in the hotel, to which they agree. While Kayla takes care of the hotel and manages the wedding with the crew, Tom and Jerry bond during their trip, but are imprisoned at a pound, after inadvertently disrupting a baseball game. A vengeful Terence separately visits Tom and Jerry, and feeds them lies of what they said to each other behind their backs, which angers them and incites them to fight at the ceremony, causing the wedding and the rest of the hotel to be destroyed.
After Kayla comes clean and leaves in shame, while Preeta renounces the wedding, a remorseful Tom and Jerry reconcile with each other and put their differences aside to fix everything up. They convince Kayla and the hotel crew, including a reluctant Terence, to salvage the wedding, while the pair lure Preeta and Toots to Central Park, where the wedding is held at. Kayla promises to Preeta that Tom and Jerry have changed their ways, and Ben apologizes to Preeta for his extensive expenses, in light of impressing her dad. Kayla and the stolen resume's owner reconcile with each other and get jobs at the hotel, while Tom strives to be a pianist and plays the piano for Toots, with Jerry joining the party, until a mishap causes them to revert to their old habits.
